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  KL Magazine June 2018

  ISSN 2044–7965

  ISSUE 93 JUNE 2018 PRICELESS

  magazine

  WEST NORFOLK | NORTH NORFOLK | COASTAL

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  COVER IMAGE Baconsthorpe Castle by Ian Ward

  meet the team MANAGING DIRECTOR Laura Dunn MANAGING EDITOR Eric Secker DESIGN TEAM Amy Phillips Lisa Tonroe PHOTOGRAPHY Ian Ward PROMOTION Nicola Back ADVERTISING Jessica Smith CONTRIBUTORS Clare Bee Abigail Brown Mike Goward Peter Jackson Paul Richards Sylvia Steele Maxine Thorne Wendy Warner

  contact 18 Tuesday Market Place King’s Lynn PE30 1JW 01553 601201 info@klmagazine.co.uk KL magazine is published monthly by KL Publications Ltd. The magazine cannot accept responsibility for unsolicited submissions, manuscripts and photographs. While every care is taken, prices and details are subject to change and KL magazine takes no responsibility for omissions or errors. We reserve the right to publish and edit any letters. All rights reserved.

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  T

  this month’s magazine features two huge and internationally-renowned talents visiting the area, both visiting locations steeped in history bu

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• Endogenous Retrovirus Insertion in the KIT Oncogene Determines White and Whitespotting in Domestic Cats

  PubMed Central

  David, Victor A.; Menotti-Raymond, Marilyn; Wallace, Andrea Coots; Roelke, Melody; Kehler, James; Leighty, Robert; Eizirik, Eduardo; Hannah, Steven S.; Nelson, George; Schäffer, Alejandro A.; Connelly, Catherine J.; O’Brien, Stephen J.; Ryugo, David K.

  2014-01-01

  The Dominant White locus (W) in the domestic cat demonstrates pleiotropic effects exhibiting complete penetrance for absence of coat pigmentation and incomplete penetrance for deafness and iris hypopigmentation. We performed linkage analysis using a pedigree segregating White to identify KIT (Chr. B1) as the feline W locus. Segregation and sequence analysis of the KIT gene in two pedigrees (P1 and P2) revealed the remarkable retrotransposition and evolution of a feline endogenous retrovirus (FERV1) as responsible for two distinct phenotypes of the W locus, Dominant White, and whitespotting. A full-length (7125 bp) FERV1 element is associated with whitespotting, whereas a FERV1 long terminal repeat (L